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Alpha 2 Macroglobulin (A2M) | Chicago Stem Cell Therapy
A2m Treatment

With approximately 30 million of the Americans suffering from arthritic and degenerative conditions, scientists and other researchers have found a new biological treatment in the field of regenerative medicine known as Alpha 2 Macroglobulin. The main goal of this injection is to target the most common health problems that the people face today.


A2M injection therapy also known as Alpha 2 macroglobulin is described to be a therapy that utilizes proven scientific techniques and natural healing methods with the help of which conditions like arthritis and osteoarthritis are treated efficiently. With the passage of time, we all know that the cartilage tends to break down in people affecting the overall joints. The Alpha 2 Macroglobulin assists in putting a stop to the cartilage breakdown, help promote tissue growth and give an overall restoration to the affected joint.


The Alpha 2 Macroglobulin is made up of four identical subunits that are bound together by –S-S- bonds. Each Alpha 2 Macroglobulin’s monomer comprises of many functional domains namely

  • macroglobulin domains
  • a thiol ester-containing domain
  • a receptor-binding domain

There is scientific evidence present that proves that alpha 2 macroglobulin treatment is playing pivotal role in treating the patients of osteoarthritis. In fact it has the ability of stopping osteoarthritis at the molecular level. A2M is the broad spectrum multipurpose protease inhibitor; an important powerful chemical that is responsible for the destruction of proteins that lead to arthritis. A2M works by trapping the bad chemicals and quickly freeing the body from it.

Regarding the A2M treatment, a significant study has elaborated that when the concentration of A2M in a specific joint becomes insufficient for the purpose of joint protection, a joint injection containing a high concentration of A2M is injected that stimulates cartilage protection by stopping the progression of arthritis.

There are not all joints that respond best to this injection, but the A2M treatment encloses with it a special type of test called as fibronectin-aggrecan G3 complex test (FAC). With this test the levels of a specific type of protein is calculated which is the one that helps in the diagnosis of arthritis.

Regarding arthritis, in a nut shell, the alpha 2 macroglobulin treatment not only helps stop osteoarthritis on its initial level but also keeps the patient away from a protein that can cause the pain in the joints.


The injection of alpha 2 macroglobulin helps in the obstruction of the breakdown of the cartilage and discourages the proteins in the joints that are inflammatory. Moreover, it is best for the people suffering from an injury in an arthritic situation as it prevents the progression of arthritis towards the affected joints. Today, the a2m injection is becoming more renowned as an important part of the regenerative therapies that will not only help restore the joints, prevent arthritis but also assist in the treatment of low back pain.